Table 2.
Drug exposure
| Young (n = 243) | Middle age (n = 494) | Elderly (n = 300) | Old (n = 52) | |
|---|---|---|---|---|
| Duration of exposure, days (median, range) | 722.00 (46–821) | 724 (5–793) | 724 (1–798) | 709 (4–780) |
| Time of treatment, days (median, range) | 728 (46–960) | 728 (5–888) | 728 (1–817) | 718 (4–780) |
| Average daily dose, mg/day, (mean ± SD) | 583.1 ± 50.7 | 587.0 ± 46.4 | 577.6 ± 66.4 | 576.5 ± 64.9 |
| Dose intensity, mg/day (median, range) | 600 (257.8–620.5) | 600 (144.4–689.0) | 600 (173.9–625.7) | 598.5 (300.0–600.0) |
| Dose reductions, n (%) | 71 (29.2%) | 146 (29.6%) | 90 (30.0%) | 14 (26.9%) |
| 1 Dose reduction | 32 (13.2) | 76 (15.4) | 46 (15.3) | 6 (11.5) |
| 2 Dose reductions | 15 (6.2) | 30 (6.1) | 20 (6.7) | 5 (9.6) |
| >2 Dose reductions | 24 (9.9) | 40 (8.1) | 24 (8) | 3 (5.8) |
| Dose interruptions, n (%) | 84 (34.6%) | 168 (34.0%) | 113 (37.7%) | 22 (42.3%) |
| 1 Dose interruption | 39 (16.1) | 95 (19.2) | 57 (19.0) | 14 (26.9) |
| 2 Dose interruptions | 20 (8.2) | 44 (8.9) | 21 (7.0) | 4 (7.7) |
| >2 Dose interruptions | 25 (10.3) | 29 (5.9) | 35 (11.7) | 4 (7.7) |