Table 4.
Most frequent all grades (≥10% in any group) nonhematological adverse events (AEs)
| AEs | Young (n = 243), n (%) | Middle age (n = 494), n (%) | Elderly (n = 300), n (%) | Old (n = 52), n (%) | ||||
|---|---|---|---|---|---|---|---|---|
| All grades | Grade 3 or 4 | All grades | Grade 3 or 4 | All grades | Grade 3 or 4 | All grades | Grade 3 or 4 | |
| Abdominal pain | 33 (13.6) | 1 (0.4) | 74 (15.0) | 5 (1.0) | 45 (15.0) | 2 (0.7) | 8 (15.4) | – |
| Rash | 52 (21.4) | 1 (0.4) | 123 (24.9) | 1 (0.2) | 52 (17.3) | 1 (0.3) | 6 (11.5) | – |
| Pruritus | 33 (13.6) | 1 (0.4) | 83 (16.8) | 1 (0.2) | 55 (18.3) | 1 (0.3) | 9 (17.3) | – |
| Fatigue | 31 (12.8) | 1 (0.4) | 76 (15.4) | 4 (0.8) | 41 (13.7) | 1 (0.3) | 3 (5.8) | – |
| Headache | 51 (21.0) | 5 (2.1) | 86 (17.4) | 3 (0.6) | 25 (8.3) | – | 4 (7.7) | – |
| Nausea | 19 (7.8) | 2 (0.8) | 59 (11.9) | – | 35 (11.7) | 3 (1.0) | 10 (19.2) | – |
| Nasopharyngitis | 36 (14.8) | – | 44 (8.9) | – | 31 (10.3) | – | 2 (3.8) | – |
| Alopecia | 25 (10.3) | 1 (0.4) | 59 (11.9) | – | 24 (8.0) | – | 7 (13.5) | – |
| Dry skin | 17 (7.0) | – | 43 (8.7) | – | 30 (10.0) | – | 3 (5.8) | – |
| Myalgia | 26 (10.7) | 1 (0.4) | 52 (10.5) | – | 19 (6.3) | 1 (0.3) | 2 (3.8) | – |
| Muscle spasm | 13 (5.3) | – | 48 (9.7) | – | 30 (10.0) | – | 2 (3.8) | – |
| Diarrhea | 16 (6.6) | - | 39 (7.9) | 1 (0.2) | 35 (11.7) | 1 (0.3) | 4 (7.7) | – |