Table 2.
Levels of monoamine neurotransmitters in individual brain regions.
| Region | G | DOPAC | DA | HVA | 5-HT | 5-HIAA | 3-MT |
|---|---|---|---|---|---|---|---|
| PFC | +/+ | 0.25 ± 0.03 | 0.52 ± 0.05 | 0.44 ± 0.05 | 8.58 ± 0.42 | 2.40 ± 0.22 | nd |
| -/- | 0.24 ± 0.02 | 0.45 ± 0.07 | 0.43 ± 0.05 | 8.67 ± 0.58 | 2.50 ± 0.15 | nd | |
| RSD | +/+ | 0.12 ± 0.02 | 0.05 ± 0.03 | 0.19 ± 0.05 | 7.87 ± 0.85 | 2.40 ± 0.22 | nd |
| -/- | 0.11 ± 0.02 | 0.03 ± 0.01 | 0.22 ± 0.05 | 6.74 ± 0.55 | 2.19 ± 0.16 | nd | |
| NAc | +/+ | 10.26 ± 0.87 | 101.89 ± 10.34 | 10.87 ± 1.01 | 10.01 ± 1.19 | 5.56 ± 0.63 | 5.82 ± 0.67 |
| -/- | 11.55 ± 0.90 | 119.34 ± 15.86 | 11.07 ± 1.06 | 11.21 ± 0.76 | 5.84 ± 0.43 | 6.76 ± 0.54 | |
| BLA | +/+ | 4.23 ± 0.51 | 58.37 ± 15.86 | 6.91 ± 0.80 | 15.47 ± 2.47 | 5.84 ± 0.65 | 3.68 ± 0.73 |
| -/- | 2.88 ± 0.27∗ | 23.60 ± 4.69∗ | 4.40 ± 0.42∗∗ | 19.01 ± 2.45 | 5.95 ± 0.49 | 2.06 ± 0.42 | |
| Hip-D | +/+ | 0.24 ± 0.04 | 0.70 ± 0.39 | 0.51 ± 0.06 | 15.16 ± 1.77 | 8.30 ± 0.83 | nd |
| -/- | 0.26 ± 0.04 | 0.42 ± 0.18 | 0.49 ± 0.08 | 13.89 ± 0.85 | 8.04 ± 0.66 | nd | |
| Hip-V | +/+ | 0.30 ± 0.07 | 0.32 ± 0.14 | 0.33 ± 0.07 | 21.47 ± 1.18 | 9.04 ± 0.90 | nd |
| -/- | 0.22 ± 0.03 | 0.23 ± 0.07 | 0.43 ± 0.09 | 23.39 ± 1.59 | 10.81 ± 0.85 | nd | |
| SNR | +/+ | 2.67 ± 0.29 | 8.45 ± 1.23 | 4.77 ± 0.45 | 32.44 ± 5.01 | 11.37 ± 0.87 | 0.86 ± 0.29 |
| -/- | 2.37 ± 0.39 | 7.95 ± 1.62 | 4.59 ± 0.59 | 29.78 ± 4.61 | 10.90 ± 1.26 | 2.94 ± 2.02 | |
| VTA | +/+ | 5.65 ± 0.60 | 18.72 ± 2.27 | 6.50 ± 0.55 | 20.72 ± 2.51 | 12.13 ± 1.01 | 1.27 ± 0.36 |
| -/- | 6.30 ± 0.64 | 20.14 ± 3.01 | 7.23 ± 0.66 | 22.54 ± 2.45 | 13.95 ± 1.62 | 1.56 ± 0.35 | |
| PRh | +/+ | 0.12 ± 0.05 | 0.70 ± 0.16 | 0.52 ± 0.16 | 13.36 ± 2.68 | 3.05 ± 0.53 | nd |
| -/- | 0.10 ± 0.04 | 0.73 ± 0.13 | 0.36 ± 0.11 | 12.60 ± 1.72 | 3.04 ± 0.37 | nd | |
| MnR | +/+ | 1.96 ± 0.46 | 2.19 ± 1.03 | 4.11 ± 0.68 | 28.00 ± 3.50 | 24.06 ± 3.57 | nd |
| -/- | 1.05 ± 0.16 | 0.63 ± 0.29 | 1.93 ± 0.34∗ | 26.60 ± 3.99 | 20.99 ± 2.44 | nd | |
| DRD | +/+ | 1.47 ± 0.16 | 2.57 ± 0.37 | 2.06 ± 0.40 | 48.37 ± 6.45 | 23.67 ± 2.56 | nd |
| -/- | 1.38 ± 0.12 | 2.33 ± 0.29 | 1.43 ± 0.23 | 35.70 ± 3.46 | 17.39 ± 1.22∗ | nd | |
| SC | +/+ | 0.29 ± 0.03 | nd | 0.87 ± 0.10 | 7.35 ± 0.68 | 1.43 ± 0.10 | nd |
| -/- | 0.29 ± 0.04 | nd | 0.92 ± 0.09 | 7.96 ± 0.69 | 1.46 ± 0.09 | nd | |
| MC | +/+ | 0.19 ± 0.02 | 0.07 ± 0.01 | 0.48 ± 0.05 | 10.38 ± 0.89 | 1.85 ± 0.18 | nd |
| -/- | 0.19 ± 0.02 | 0.07 ± 0.02 | 0.46 ± 0.03 | 10.76 ± 0.89 | 1.90 ± 0.15 | nd | |
| Stri | +/+ | 15.84 ± 0.55 | 296.94 ± 21.99 | 21.47 ± 0.91 | 10.20 ± 1.22 | 6.00 ± 0.76 | 11.96 ± 0.60 |
| -/- | 15.96 ± 1.09 | 282.74 ± 20.76 | 21.06 ± 1.44 | 8.11 ± 0.60 | 5.77 ± 0.36 | 10.91 ± 0.73 | |
| OB | +/+ | 1.24 ± 0.13 | 2.68 ± 0.14 | 1.92 ± 0.13 | 9.70 ± 1.09 | 2.81 ± 0.24 | 0.41 ± 0.06 |
| -/- | 1.02 ± 0.08 | 3.46 ± 0.24∗ | 1.51 ± 0.10∗ | 14.46 ± 0.72∗ | 3.17 ± 0.12 | 0.45 ± 0.11 | |
| AHC | +/+ | 1.50 ± 0.12 | 4.82 ± 0.25 | 2.64 ± 0.33 | 26.60 ± 1.87 | 8.22 ± 0.41 | 0.53 ± 0.44 |
| -/- | 1.45 ± 0.14 | 4.11 ± 0.59 | 2.01 ± 0.20 | 25.96 ± 2.61 | 8.39 ± 0.50 | 0.42 ± 0.30 |
Levels of monoamines and their metabolites are expressed as pmol/mg protein. Values are mean ± SEM. ∗p < 0.05, ∗∗p < 0.01 vs. ATF5+/+ mice. +/+, ATF5+/+ mice; -/-, ATF5-/- mice; G, genotype; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; HVA, homovanillic acid; 5-HT, serotonin; 5-HIAA, 5-hydroxyindol acetic acid; 3-MT, 3-methoxytyramine; nd, not determined.