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. 2017 Jul 11;8:456. doi: 10.3389/fphar.2017.00456

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Copyright © 2017 Han, Wang, Ye, Li, Hao, Chen, Ma, Wang, Shang, Li and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of RosA on cardiac function in rat I/R model. The effect of RosA on LVDP (A), dp/dtmax (B), dp/dtmin (C), and CF (D) in rat hearts. Control, healthy control mice; I/R, ischemia/reperfusion model mice; RosA, healthy mice treated with RosA; PIO, healthy mice treated with pioglitazone; GW9662, healthy mice treated with GW9662; T0070907, healthy mice treated with T0070907; RosA+I/R, I/R mice treated with RosA; PIO+I/R, I/R mice treated with PIO; RosA+GW9662+I/R, I/R mice treated with RosA plus GW9662; RosA+T0070907+I/R, I/R mice treated with RosA plus T0070907; PIO+GW9662+I/R, I/R mice treated with PIO plus GW9662; PIO+T0070907+I/R, I/R mice treated with PIO plus T0070907. Values are presented as means with their standard deviation, n = 6. Compared with the control group, ^#P < 0.05, ^##P < 0.01. Compared with the I/R group, ^∗P < 0.05, ^∗∗P < 0.01. Compared with the I/R+RosA group, ^$P < 0.05, ^$$P < 0.01. Compared with the I/R+PIO group, ^&P < 0.05, ^&&P < 0.01.