Table 4.

Potential marker metabolites in mice spleen identified by ¹H-NMR and their fold changes among groups and the associated p-values.

No.	Metabolite	Model vs. Control		CNC vs. Model		JHC vs. Model
		FCa	p-valueb	FC	p-value	FC	p-value
1	Isoleucine	1.16		0.8	***	0.87
2	Leucine	1.11		0.83	*	0.86
3	Valine	1.09		0.91		0.89
4	Lactate	0.81	*	1.3		1.21	***
5	Threonine	1.72	*	0.62	***	0.57	***
6	Alanine	0.99		0.94		1
7	Lysine	1.07		0.96		0.92
8	Acetate	1.04		1.34	***	1.03
9	Methionine	1.09		0.89		0.92
10	Glutamate	1.15	***	0.82	***	0.87	***
11	Glutamine	0.96		1.1	*	1.12	**
12	Glutathione	1.14		0.69	**	0.71	***
13	Aspartate	1.08		0.78	**	0.89	*
14	Dimethylamine	1.04		0.96		1.02
15	Creatine	1.12		0.88		0.81	***
16	PCr	1.12		0.88	*	0.81	***
17	Choline	0.95		1.14	*	1.16	***
18	OPC	1.07		0.96		1.05
19	Betaine	0.88		1.03		1.14	*
20	Taurine	0.94		1.07		1.08	**
21	Glucose	1.24	**	0.8	*	0.8	***
22	Maltose	1.24	**	0.8	*	0.8	***
23	Glycine	0.91		1.12		1.17	*
24	Uridine	0.96		1.05		1.14
25	Inosine	0.87		0.67	***	0.82	***
26	Fumarate	0.94		1.05		1.04
27	Tyrosine	0.97		0.93		0.98
28	Phenylalanine	0.96		0.88		0.93
29	Hypoxanthine	1.03		0.92		0.96
30	Histidine	1.07		1.03		0.98
31	Nicotinurate	0.71	*	1.25		1.23
32	Cytosine	0.85		1.19		1.05
33	Guanosine	0.83		1.5		2.22
34	UDP-galactose	0.89		0.9		1.1
35	Formate	1.02		1.53		1.18

^aColor coded according to the fold change value, red represents increased and blue represents decreased concentrations of metabolites.

^bp-values corrected by BH (Benjamini Hochberg) methods were calculated based on a parametric Student's t-test or a nonparametric Mann-Whitney test (dependent on the conformity to normal distribution).

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.