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. 2016 Nov 30;222(5):2345–2357. doi: 10.1007/s00429-016-1345-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Reduced tonic cannabinoid signaling by irradiation. Representative traces of paired recordings from presynaptic CB₁BCs (top, AP) and postsynaptic PCs (bottom, IPSCs) in control ACSF (Control) and during application of AM251 from control group (a) and irradiated group (d). Summary of the effects of AM251 on euIPSCs in control (b) and irradiated (e) groups. Percent of presynaptic APs resulting in successful IPSCs (successes) in the postsynaptic cell in control (c) and irradiated (f) groups. Application of AM251 causes more of an increase in euIPSCs (g) and successes (h) in controls than after irradiation. After application of AM251, the amplitude of euIPSCs (i) and successes (j) are not different between groups (n = 7 pairs, 0 Gy; n = 8 pairs, 0.5 Gy)