Figure 4.

Targeting ROS homeostasis as a strategy for changing cell fate. In proliferative conditions, such as cancer, targeting antioxidant systems could move the redox state of the cell to either promote normal redox homeostasis or apoptosis (strategies a and c, respectively). Unsuccessful tackling of antioxidant metabolism results in the cells maintaining a proliferative state, which potentially enhances malignancy. The three lines represent the high heterogeneity between individuals, tissues, and cancer types.