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. 2017 Jul 5;8:16048. doi: 10.1038/ncomms16048

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a–c) We assumed that the stability of the major states should be underpinned by functional segregation between a DMN/Visual module and an FPN/SAN/ATN/SMN/Auditory module (a,b). The across-network functional segregation was significantly stronger in the ASD group than in the controls (c). (d–g) In the ASD group, the atypically strong functional segregation was correlated with the major state frequency (d), the duration of the major states (e) and the FIQ scores (f). These results imply that aberrantly strong functional segregation in autism overly may stabilize brain dynamics, which would be related to their cognitive skills (g).