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. 2017 Jul 5;8:16048. doi: 10.1038/ncomms16048

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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We confirmed that such across-network functional segregation underlay the brain dynamics of neurotypical individuals. Here we calculated the strength of functional segregation related to the intermediate state (a), and showed significant correlations between the functional segregation strength and (i) the intermediate-state frequency, (ii) the indirect transition frequency and (iii) FIQ scores (b). These results suggest that in TD individuals functional segregation between the specific two network modules may stabilize the intermediate state and ensure the flexibility of brain dynamics, which would be associated with general cognitive ability (c).