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. 2017 Jul 5;8:16079. doi: 10.1038/ncomms16079

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a,c) Change in expression of mature miRNAs of the miR-17-92 cluster (a) and primary transcripts of miR-17-92 (c) in the L5 DRG over time after SNL. Numbers of samples are indicated at the base of each bar. *P<0.05, **P<0.01 and ***P<0.001 (miR-17, P=0.002 for 1d, P=0.010 for 3d, P=0.017 for 7d, P=0.004 for 14d and P<0.001 for 28d; miR-18a, P=0.006 for 1d, P=0.011 for 3d, P=0.005 for 7d, P<0.001 for 14d and P<0.001 for 28d; miR-19a, P=0.017 for 1d, P=0.033 for 3d, P=0.022 for 7d, P<0.001 for 14d and P<0.001 for 28d; miR-19b, P=0.002 for 1d, P=0.049 for 3d, P=0.005 for 7d, P=0.002 for 14d and P<0.001 for 28d; miR-20a, P=0.008 for 1d, P=0.015 for 3d, P=0.020 for 7d, P<0.001 for 14d and P<0.001 for 28d; miR-92a, P=0.006 for 1d, P=0.016 for 3d, P=0.011 for 7d, P=0.002 for 14d and P<0.001 for 28d; pri-miR-17-92, P=0.043 for 1d, P=0.005 for 3d, P=0.048 for 7d, P=0.022 for 14d and P=0.011 for 28d) compared with the contralateral intact side, paired t-test. (b) Paw withdrawal responses to mechanical stimuli evaluated on the SNL and contralateral sides. Error bars are s.e.m. *P<0.05 (P=0.043 for 3d, P=0.042 for 7d, P=0.041 for 14d and P=0.039 for 28d) compared with the contralateral side, Mann–Whitney U test.