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. 2017 Jul 5;8:16079. doi: 10.1038/ncomms16079

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) List of voltage-gated potassium channel subunits predicted as miR-17-92 target genes; these subunits were reportedly downregulated in a previous microarray study of SNL²⁰. Parenthesized targeting miRNAs represent predicted miRNAs not validated by a luciferase assay. (b) Activities of luciferase with voltage-gated potassium channel subunit 3′-UTRs or mutated 3′-UTRs in HEK293 cells co-transfected with control or miR-17-92 cluster member-expressing plasmid vector. Numbers of cell cultures are indicated at the base of each bar. Error bars are s.e.m. *P<0.05, **P<0.01 and ***P<0.001 (Kcna1, P<0.001 for miR-18a and P=0.004 for miR-92a; Kcna4, P<0.001 for miR-19a and P<0.001 for miR-19b; Kcnc4, P<0.001 for miR-19a, P<0.001 for miR-19b and P<0.001 for miR-92a; Kcnd3, P=0.021 for miR-18a; Kcnq5, P=0.008 for miR-19a and P=0.008 for miR-19b; Dpp10, P=0.006 for miR-92a; Scn1b, P<0.001 for miR-19a and P<0.001 for miR-19b) compared with control plasmid, unpaired t-test or Dunnett’s test.