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. 2017 Jun 19;6(7):1787–1798. doi: 10.1002/cam4.1120

Table 1.

BRCA1/2 Mutation risk categories

High risk – Women were categorized as high mutation risk if they met any of the five criteria below:

  1. Diagnosed ≤40 years

  2. Diagnosed ≤50 years AND:
    1. First‐ or second‐degree female relative diagnosed with breast cancer ≤50 years OR First‐ or second‐degree relative with ovarian cancer

  3. First‐ or second‐degree male relative with breast cancer

  4. Two relatives with breast or ovarian cancer at any age in the same lineage

  5. Ashkenazi Jewish ancestry

Moderate risk – Women were categorized as moderate mutation risk if they did not meet high‐risk criteria and met either of the two criteria below:
  1. Diagnosed 41–49 years AND:
    • a
      A relative with breast cancer diagnosed >50 years OR No family history of cancer
  2. Diagnosed ≥50 years AND:
    • b
      Any family history of breast or ovarian cancer
Low risk – Women were categorized as low mutation risk if they did not meet criteria for high or moderate risk, that is,

  1. Diagnosed ≥50 years AND No family history of breast or ovarian cancer