Table 3.
Mutation frequency as determined by next‐generation sequencing
| Biomarker | Number tested | Number altered | % altered |
|---|---|---|---|
| ABL1 | 442 | 0 | 0.0 |
| AKT1 | 451 | 9 | 2.0 |
| ALK | 453 | 0 | 0.0 |
| APC | 452 | 1 | 0.2 |
| ATM | 442 | 1 | 0.2 |
| BRAF | 537 | 0 | 0.0 |
| BRCA1 | 221 | 2 | 0.9 |
| BRCA2 | 222 | 3 | 1.4 |
| CDH1 | 452 | 0 | 0.0 |
| c‐KIT | 507 | 0 | 0.0 |
| cMET | 453 | 0 | 0.0 |
| CSF1R | 451 | 0 | 0.0 |
| CTNNB1 | 453 | 8 | 1.8 |
| EGFR | 458 | 0 | 0.0 |
| ERBB2 | 448 | 0 | 0.0 |
| ERBB4 | 449 | 0 | 0.0 |
| FBXW7 | 450 | 29 | 6.4 |
| FGFR1 | 453 | 0 | 0.0 |
| FGFR2 | 452 | 0 | 0.0 |
| FLT3 | 452 | 0 | 0.0 |
| GNA11 | 403 | 0 | 0.0 |
| GNAQ | 350 | 0 | 0.0 |
| GNAS | 453 | 1 | 0.2 |
| HNF1A | 408 | 2 | 0.5 |
| HRAS | 373 | 3 | 0.8 |
| IDH1 | 452 | 0 | 0.0 |
| JAK2 | 453 | 0 | 0.0 |
| JAK3 | 452 | 0 | 0.0 |
| KDR | 453 | 0 | 0.0 |
| KRAS | 567 | 11 | 1.9 |
| MLH1 | 451 | 0 | 0.0 |
| MPL | 449 | 0 | 0.0 |
| NOTCH1 | 448 | 0 | 0.0 |
| NPM1 | 451 | 0 | 0.0 |
| NRAS | 502 | 2 | 0.4 |
| PDGFRA | 451 | 0 | 0.0 |
| PIK3CA | 527 | 136 | 25.8 |
| PTEN | 432 | 14 | 3.2 |
| PTPN11 | 452 | 0 | 0.0 |
| RB1 | 445 | 3 | 0.7 |
| RET | 442 | 0 | 0.0 |
| SMAD4 | 452 | 1 | 0.2 |
| SMARCB1 | 451 | 0 | 0.0 |
| SMO | 361 | 0 | 0.0 |
| STK11 | 434 | 2 | 0.5 |
| TP53 | 446 | 0 | 0.0 |
| VHL | 405 | 0 | 0.0 |