Table 4.

Comparison of cancer agents according to NCCN guidelines for HPV‐induced cancers

Drug Type	Predictive Biomarkers	ASCC	CSCC	OSCC	VSCC
Cytotoxic Therapies	ERCC1, BRCA1/2	cisplatin	cisplatin, carboplatin	cisplatin, carboplatin	cisplatin
	TS	5‐fluorouracil, capecitabine	5‐fluorouracil, pemetrexed	5‐fluorouracil, capecitabine	5‐fluorouracil
	TUBB3/TLE3/PGP		paclitaxel, docetaxel, vinorelbine	paclitaxel, docetaxel	paclitaxel, vinorelbine
	TOPO1		topotecan, irinotecan
	RRM1		gemcitabine
	BRCA1/2	mitomycin‐C	mitomycin‐C		mitomycin‐C
Targeted Therapies	none identified		bevacizumab	cetuximab