Table 2.
Copy number variation and expression levels of nuclear receptor coregulators in human colorectal cancer
| Coregulator | CNV (%) | Expression | Ref. |
| NCOA1 | Gain (5.5) | ND | |
| NCOA2 | Gain (30.1) | ↑ or ↓ | Giannini 2005, Grivas 2009, Yu 2016 |
| NCOA3 | Gain (40.6) | ↑ | Anzick 1997, Aust 2004, Xie 2005 |
| NCOA6 | Gain (42.7) | ↑ | Lee 1999 |
| PPARGC1A | Loss (8.4) | ↓ | D’Errico 2011 |
| EP300 | Loss (19.3) | ↑ | Ishihama 2007 |
| CREBBP | Gain (5.3) | ↑ | Ishihama 2007 |
| MED1 | Gain (11.8) Loss (8.4) | ↓ | Giannini 2005 |
| NCOR1 | Loss (40.4) | ↑ | Fernández-Majada 2007 |
| NCOR2 | Gain (9.8) | ↑ | Giannini 2005, Fernández-Majada 2007 |
| NRIP1 | Loss (17.2) | ↓ | Lapierre 2014 |
| MTA1 | Loss (15.0) | ↑ | Toh 1997 |
Gene copy number analysis was performed in 379 CRC samples from the “Carte d’Identité des Tumeurs de la Ligue contre le Cancer” using the Nexus Copy Number software (BioDiscovery, CA, United States). The percentage of CRC specimens showing chromosomic gains and losses are indicated (B. Orsetti, personal communication). Variations in the expression level were determined using the data extracted from the indicated references. ND: Not determined; CRC: Colorectal cancer.