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. 2017 Jul 7;23(25):4559–4568. doi: 10.3748/wjg.v23.i25.4559

Figure 6.

Figure 6

In vitro, rosuvastatin reduced the expression of inflammatory mediators and cleaved caspase-3. IEC-6 cells were treated with 50 ng/mL and/or 2 μmol/L rosuvastatin for 24 h. (A) qRT-PCR showing mRNA expression levels of IL-1β, IL-8, and COX-2. Rosuvastatin significantly attenuated mRNA levels of IL-1β, IL-8, and COX-2 in TNF-α-treated IEC-6 cells. Data are expressed as mean ± SE. (B) Western blot showing protein expression levels of COX-2 and cleaved caspase-3. Rosuvastatin significantly attenuated COX-2 and cleaved caspase-3 protein expression in 50 ng/mL TNF-α-treated IEC-6 cells. bP < 0.01 vs TNF-α-treated IEC-6 cells without rosuvastatin. TNF: Tumor necrosis factor; COX: Cyclooxygenase; Ro: Rosuvastatin.