During the night studies, the coefficient of variation (CV) for f (P = 0.038; B) and Vt (P = 0.04; C) within 15-min periods was greater for the awake state (●) than for NREM slee (○), indicated by the interaction term of two-way ANOVA (F and P at top left). A: the CV of V̇i did not differ between awake and NREM sleep. A one-way ANOVA indicated that, in the awake state at night, the triple cocktail significantly increased the CV for V̇i, f, and Vt (P < 0.05), whereas for NREM sleep, the triple cocktail only significantly increased the CV for V̇i (P = 0.039) (P, right side). The horizontal solid line in A denotes that the triple cocktail was dialyzed between 60 and 120 min. Values are means ± SE.