Fig. 8.

Unilateral dialysis of 50 mM atropine during the day (n = 6; ●) (indicated by horizontal solid line) significantly (P < 0.001) increased ventilation (V̇i; A) and breathing frequency (f; B), but did not significantly (P = 0.578) alter tidal volume (Vt; C) compared with mCSF time control studies (○). The F and P values are the interaction terms from two-way repeated-measures ANOVA using dose and time as factors. Values are means ± SE. *Values during and after atropine dialysis that differed from hour 1 mCSF dialyses, as indicated by Holm-Sidak post hoc analysis.