Fig. 5.

Mini-TyrRS lacks vasoactive actions. A: increase in perfusion (Doppler) induced in nonligated ear by raising rectal temperature from 35°C to 37.5°C was unaffected by mini-TyrRS (20-μl subcutaneous administration into ear immediately after 35°C measurement, followed by measurement 10 min later at 37.5°C). B: increase in perfusion induced by papavarine (adductor area sc) was unaffected by mini-TyrRS injected into same site 30 min earlier. C: baseline (control) ear perfusion was unaffected after 6 days of daily sc mini-TyrRS (daily dose given as two 20-μl injections 12 h apart); n = 4–6/bar.