Table 1.

Daily CQ injection prevents high-fat diet-induced obesity in mice

	NC-SL	NC-CQ	HF-SL	HF-CQ
Food intake, kcal/day	9.09 ± 0.48	9.08 ± 1.14	15.23 ± 0.28***	17.21 ± 0.36+++
Body weight, g	26.5 ± 0.5	26.1 ± 0.7	30.9 ± 0.7***	27.12 ± 0.5+++
Fat weight, g	2.98 ± 0.22	2.64 ± 0.18	9.84 ± 0.69***	5.02 ± 0.50+++,###
Lean body mass, g	20.8 ± 0.5	20.7 ± 0.8	18.6 ± 0.3*	19.4 ± 0.6
Fluid, g	1.01 ± 0.17	1.10 ± 0.16	0.50 ± 0.13	0.59 ± 0.17
%Fat	11.2 ± 0.8	10.3 ± 0.8	31.5 ± 1.3***	18.5 ± 1.8+++,###
%Lean body mass	78.3 ± 0.9	79.1 ± 0.9	60.5 ± 1.2***	71.4 ± 1.8+++,###

Values are means ± SE (n = 12). CQ, chloroquine; HF, high-fat; NC, normal chow; SL, normal saline. Adult (12 wk of age) male wild-type mice (C57BL/6) were on NC or HF diet for 8 wk with daily injection (ip) of SL or CQ (60 mg/kg).

^*P < 0.05 vs. NC-SL group;

^***P < 0.001 vs. NC-SL group; +++P < 0.001 vs. HF-SL group; ###P < 0.001 vs. NC-CQ group.