Table 1.
NC-SL | NC-CQ | HF-SL | HF-CQ | |
---|---|---|---|---|
Food intake, kcal/day | 9.09 ± 0.48 | 9.08 ± 1.14 | 15.23 ± 0.28*** | 17.21 ± 0.36+++ |
Body weight, g | 26.5 ± 0.5 | 26.1 ± 0.7 | 30.9 ± 0.7*** | 27.12 ± 0.5+++ |
Fat weight, g | 2.98 ± 0.22 | 2.64 ± 0.18 | 9.84 ± 0.69*** | 5.02 ± 0.50+++,### |
Lean body mass, g | 20.8 ± 0.5 | 20.7 ± 0.8 | 18.6 ± 0.3* | 19.4 ± 0.6 |
Fluid, g | 1.01 ± 0.17 | 1.10 ± 0.16 | 0.50 ± 0.13 | 0.59 ± 0.17 |
%Fat | 11.2 ± 0.8 | 10.3 ± 0.8 | 31.5 ± 1.3*** | 18.5 ± 1.8+++,### |
%Lean body mass | 78.3 ± 0.9 | 79.1 ± 0.9 | 60.5 ± 1.2*** | 71.4 ± 1.8+++,### |
Values are means ± SE (n = 12). CQ, chloroquine; HF, high-fat; NC, normal chow; SL, normal saline. Adult (12 wk of age) male wild-type mice (C57BL/6) were on NC or HF diet for 8 wk with daily injection (ip) of SL or CQ (60 mg/kg).
P < 0.05 vs. NC-SL group;
P < 0.001 vs. NC-SL group; +++P < 0.001 vs. HF-SL group; ###P < 0.001 vs. NC-CQ group.