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. Author manuscript; available in PMC: 2018 Feb 24.
Published in final edited form as: J Nat Prod. 2017 Jan 31;80(2):427–433. doi: 10.1021/acs.jnatprod.6b00960

Figure 4.

Figure 4

Induction of UPR by dehydrocurvularins 1–3. MDB-MA-231 cells were treated with indicated concentrations (μM) of 1–3 for 8 h. The proteins XBP1, ATF4, and CHOP were analyzed by immunoblot. DMSO and CB-5083 (C; 1.0 μM) were used as negative and positive controls, respectively. The known proteasome inhibitor MG132 (M; 5.0 μM) was included for comparison purposes, and β-actin (Actin) was used as a loading control.