Figure 6. GARP upregulation in human colon and lung cancer correlates with poor prognosis.
(A) Representative images of GARP IHC (brown color) of colon cancers with their respective patient matched normal tissue. Each patient specimen in these TMAs was represented in two cores on the slide and each core measured 1 mm in diameter. Scale bar: 20 μm. (B) Expression intensity of GARP-positive cells in colon cancer. (C) Correlation between GARP expression and overall survival of colon cancer. (D) Representative images of GARP IHC (brown color) of lung cancers with their respective patient matched normal tissue. Each patient specimen in these TMAs was represented in two cores on the slide and each core measured 1 mm in diameter. Scale bar: 20 μm. (E) Expression intensity of GARP-positive cells in lung cancer and normal lungs. (F) Correlation between GARP expression and overall survival of lung cancer. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. Statistical significance was analyzed by two-tailed Student’s t-test or Kaplan Meier analysis; the numbers of samples (n) are indicated.