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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Am J Transplant. 2015 Feb 12;15(3):815–822. doi: 10.1111/ajt.13045

Figure 2. Atacicept reduced the level of early de novo DSA.

Figure 2

(A) DSA production after atacicept treatment. The formation of donor specific antibody in serum was monitored by flow cytometry analysis. All five AMR control animals had DSA detected by 2–4 weeks posttransplantation. Reduced level of serum DSA was detected in animals receiving additional atacicept at 2 and 4 weeks (*p < 0.05 vs. AMR control) but not the time points thereafter. (B) Pearson’s correlation coefficients were calculated between DSA level versus AMR score. Serum DSA showed strong correlation (r=0.78) to the calculated AMR score among AMR control animals (circle). Abrogation of correlation between serum DSA and AMR score (r=0.14) was found by adding atacicept treated animals (rectangle).