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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Am J Transplant. 2015 Feb 12;15(3):815–822. doi: 10.1111/ajt.13045

Figure 4. Atacicept treatment reduced antibody-mediated injuries.

Figure 4

(A) Serum creatinine level of AMR controls and additional atacicept treated animals. (B) AMR related score was calculated by combining points for glomerulitis (g), allograft glomerulopathy (cg), mesangial matrix increase (mm), peritubular capillaritis (ptc) and C4d deposition. (C) The individual Banff histologic score. (D) The Banff histologic score as functional clusters (ptc + g + cg referring to microcirculation lesions, ptc + g to microcirculation inflammation, cg + mm to microcirculation deterioration, i + t to tubulointerstitial inflammation and ci + ct to tubulointerstitial scarring, and i + ci + ct + cg + cv + gs to chronic allograft damage (similar to known as CADI score (20)). Data are presented as mean, with analysis by the Mann–Whitney U-test. *p < 0.05.