Table 1.

MicroRNAs implicated in alcohol studies (2012 to 2016).

Species/Model	Region/System	miRNA(s)	Citation(s)
Human	^* PFC	miR-130a ↓	Wang, Gelernter, & Zhang, 2013
	^* FC (Broadmann 9)	multiple ↑	Manzardo et al., 2013
	^* NAc	multiple ↑↓	Mamdani et al., 2015
Rat	^* DLS	miR-124a ↓	Bahi & Dreyer, 2013
	^* NAc	miR-382 ↓	Li et al., 2013
	^* mPFC	multiple ↑↓	Tapocik et al., 2013
	Hippocampus	miR-10a-5p, miR-26a, miR-103, miR-495	Prins, Przybycien-Szymanska, Rao, & Pak, 2014
	^* mPFC	miR-206 ↑ manipulation^a	Tapocik et al., 2014
	Amygdala	miR-494 ↓	Teppen et al., 2015
	^* PFC	miR-125a-5p ↓	Tian et al., 2016
Mouse	^* FC and midbrain	multiple ↑↓	Gorini, Nunez, & Mayfield, 2013
	^* FC	multiple ↑↓	Nunez, Truitt, Gorini, Ponomareva, Harris, et al., 2013
	^* mPFC	miR-30a-5p ↑ manipulation^a	Darcq et al., 2015
	Amygdala	multiple ↑↓	Most et al., 2016
Cell Culture	Primary mouse cortical neurons	miR-155, miR-186, miR-24, and miR-375 ↑	Bekdash & Harrison, 2015
	Primary mouse microglial cells	miR-339-5p ↑	Zhang, Wei, Di, & Zhao, 2014
	Primary rat cortical neurons	miR-125a-5p ↓ manipulation^a	Tian et al., 2016

Frontal cortex (FC); Prefrontal cortex (PFC); Medial prefrontal cortex (mPFC); nucleus accumbens (NAc); dorsal striatum (DLS)

^↑upregulated; ^↓downregulated; ^↑↓both up- and down-regulation of multiple miRNAs

manipulation; specific manipulation with viral vectors, miRNA mimics, or antagomirs