Table 5.

Comparison of 4vHPV versus other HPV vaccines regarding solicited local and systemic symptoms

Components	Studies, n	Subjects, n	Pooled RR [95% CI]	Reference
Pain	3	1845	0.89 [0.75, 1.05]	[28, 29, 45]
Redness	2	1246	0.70 [0.46, 1.07]	[28, 29]
Swelling	3	1845	0.71 [0.57, 0.88]	[28, 29, 45]
Fatigue	2	1250	0.82 [0.73, 0.92]	[28, 29]

Other HPV vaccines stand for 2vHPV and 9vHPV

Two studies [28, 29] compare 4vHPV with 2vHPV and one study [45] compares 4vHPV with 9vHPV

Abbreviations: HPV human papillomavirus, 2vHPV bivalent human papillomavirus, 4vHPV quadrivalent human papillomavirus, RR risk ratio, CI confidence interval