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. 2017 Jul 11;18:333. doi: 10.1186/s12859-017-1742-5

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Theoretical Power. Top: Power curves as a function of ρ, for a fixed cohort size n=100 and varying region width p ₀=3,5,10,20. Bottom: Same graphs for a region of fixed width p ₀=5 but varying cohort sizes n=10,50,200,1000. In all graphs ρ ₀ is fixed at 0.15. The nominal level α of the test is set to 5% (left), 0.5% (center), 0.05% (right)