Table 2.
Sensitivity, specificity, PPV, NPV, LR+, and LR– of BDG and PCT used separately for the diagnosis of candidaemia over bacteraemia in the study population
| No./total patients | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cut-off | Candidaemia (TP/total) | Bacteraemia (TN/total) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR– |
| BDG | ||||||||
| ≥80 pg/ml | 67/73 | 75/93 | 92 | 81 | 79 | 93 | 4.74 | 0.10 |
| ≥100 pg/ml | 65/73 | 76/93 | 89 | 82 | 79 | 90 | 4.87 | 0.13 |
| ≥113 pg/ml | 65/73 | 78/93 | 89 | 84 | 81 | 91 | 5.52 | 0.13 |
| ≥120 pg/ml | 65/73 | 78/93 | 89 | 84 | 81 | 91 | 5.52 | 0.13 |
| ≥140 pg/ml | 60/73 | 82/93 | 82 | 88 | 85 | 86 | 6.95 | 0.20 |
| ≥160 pg/ml | 60/73 | 83/93 | 82 | 89 | 86 | 86 | 7.64 | 0.20 |
| ≥180 pg/ml | 57/73 | 85/93 | 78 | 91 | 88 | 84 | 9.08 | 0.24 |
| ≥200 pg/ml | 55/73 | 88/93 | 75 | 95 | 92 | 83 | 14.01 | 0.26 |
| PCT | ||||||||
| <0.50 ng/ml | 30/73 | 80/93 | 41 | 86 | 70 | 65 | 2.94 | 0.68 |
| <1.00 ng/ml | 46/73 | 75/93 | 63 | 81 | 72 | 74 | 3.26 | 0.46 |
| <1.93 ng/ml | 61/73 | 64/93 | 84 | 69 | 68 | 84 | 2.68 | 0.24 |
| <2.00 ng/ml | 61/73 | 62/93 | 84 | 67 | 66 | 84 | 2.51 | 0.25 |
| <3.00 ng/ml | 63/73 | 54/93 | 86 | 58 | 62 | 84 | 2.06 | 0.24 |
| <4.00 ng/ml | 67/73 | 49/93 | 92 | 53 | 60 | 89 | 1.94 | 0.16 |
| <5.00 ng/ml | 69/73 | 43/93 | 95 | 46 | 58 | 91 | 1.76 | 0.12 |
BDG (1,3)-β-d-glucan, LR+ positive likelihood ratio, LR– negative likelihood ratio, NPV negative predictive value, PCT procalcitonin, PPV positive predictive value, TN true negatives, TP true positives