Fig. 4.

Simulated tumor growth of MB231 cells under different conditions. a We investigate three doses of a drug treatment targeting cancer stem cells starting at day 150 with varying efficacy at killing cancer stem cells between 50%–90%. Plot of the mean total cell numbers over time after multiple doses of treatment. b Plot of the mean stem cell numbers over time after multiple doses of a drug treatment targeting cancer stem cells. c A semi-log plot comparison of MB231 primary tumors under control, hypoxic, and maraviroc conditions. d A plot of MB231 primary tumor under control, hypoxic, and maraviroc conditions