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. 2017 Jul 11;16:117. doi: 10.1186/s12934-017-0730-9

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Heat maps (red upregulated; white not regulated; blue downregulated) depicting the regulatory trends of potential marker genes for nutrient limitation during the methanol or glucose fed-batch process. Genes involved in transport, metabolism and regulation of phosphorus, nitrogen, and sulfur are shown. Log₂FC are calculated compared to transcript levels of glycerol FB. More intense coloring indicates stronger regulation