Table 1.
Characteristic of the patients
| Nr | size of SCLN in mm | FNAC | core biopsy | diagnosis from SCLN biopsy | immunhistochemistry | molecular testing for driver mutations | tumor history besides suspicion for lung cancer | distant metastases | other biopsies | targeted theraphy |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 15 | diagnostic | diagnostic | NSCLC (adenoca) | CK +, TTF1 +, Napsin A+ | negative | none | none | bronchoscopic biopsy before PET/CT not diagnostic | |
| 2 | 16 | diagnostic | not performed | SCLC | CD56 +,TTF1 -,mib1 > 90% | not performed | none | liver | none | |
| 3 | 21 | diagnostic | diagnostic | NSCLC (adenoca) | TTF1 +, BerEP4 + | ALK Rearrengement (confirmation in brain metastasis) | none | bone, brain, abdominal In | not enough material from bronchoscopic biopsy for mutation analysis, | crizotinib |
| 4 | 20 | diagnostic | diagnostic | NSCLC (squamous cell ca.) | p63 +, CK5/6 +, CK7-, CK20-, TTF1 -, mib1 50-80% | negative | none | abdominal In, lung, kidney | SCLN biopsy and later bronchoscopic biopsy performed | |
| 5 | 22 | not performed | diagnostic | NSCLC (adenoca) | CK7 +, TT1 -, Napsin A -, p63 -, CK 5/6 -, BerEP4 + | negative | urothelca, urethra | bone, adrenal, abdominal In | none | |
| 6 | 16 | diagnostic | diagnostic | NSCLC (squamous cell ca.) | p63 +, CK5/& +, TTF1 -, CK7 (+) | negative | none | pleura | broncho positive | |
| 7 | 10 | diagnostic | not performed | NSCLC (adenoca) | TTF1 + | lung biopsy: pF1 2 V KRAS | none | none | none | |
| 8 | 13 | diagnostic | diagnostic | NSCLC (adenoca) | TTF1 +, CK5/6 - | lung lobectomy: KIF5B-RET Translokation | malignant melanoma | lung, abdominal In | none | vandetanib, cabozantinib |
| 9 | 14 | diagnostic | diagnostic | granulomas (sarcoidosis) | not performed | not performed | breast cancer | none | none | |
| 10 | 11 | diagnostic | not diagnostic | NSCLC (adenoca) | TTF1 + | negative | none | none | none | |
| 11 | 7 | diagnostic | diagnostic | breast cancer (adenoca.) | CK7 +, BRST +, TTF1 - | negative | breast cancer, bilateral lung cancer | none | CT biopsy lung | |
| 12 | 10 | diagnostic | diagnostic | NSCLC (adenoca) | CK7+, TTF1+ | Del p.E746_A750del in Exon 19 von EGFR | prostate camcer, urothelca, urinary | none | none | afatinib |
abbreviations: NSCLC, non-small cell lung cancer, SCLC small cell lung cancer, ln lymph node, FNAC fine needle aspiration cytology, SCLN supraclavicular lymph node