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. 2017 Jul 11;15:56. doi: 10.1186/s12969-017-0183-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Distribution of bone metabolism markers in boys and girls according to age. Median and ±1.88SD values were referenced from a previous report [23]. (a and b) BAP and TRAP5b in boys with CNO were higher than that in the age-matched normal population, indicating higher bone metabolic turnover in boys with CNO. (c and d) BAP and TRAP5b in girls with CNO aged <10 years were higher than that in the age-matched normal population. These bone metabolic biomarkers were relatively lower in girls with CNO aged >10 years. BAP, bone alkaline phosphatase; TRAP5b, tartrate-resistant acid phosphatase serum band 5; CNO, chronic nonbacterial osteomyelitis