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. 2017 Jul 11;15:56. doi: 10.1186/s12969-017-0183-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Representative case of a 5-year-old girl with CNO. The patient had a 3-month history of pain in both knees, and achieved clinical remission after the initial treatment. (a) Radiographic examination showed sclerosis in the distal metaphysis of both femurs. (b) FDG-PET image demonstrating increased multiple FDG uptakes in both distal femurs and right proximal tibia. (c) T2-STIR MRI scan at first presentation showing high signal in both distal femurs and right proximal tibia. (d) T2-STIR MRI scan at 6 months after the initiation of first-line treatment showing remission of high signals in both femurs and right tibia. CNO, chronic nonbacterial osteomyelitis; FDG-PET, fluorodeoxyglucose-positron emission tomography; T2-STIR MRI, T2-signal intensity in short tau inversion recovery magnetic resonance imaging