Table 1.
Clinical, laboratory, and demographic features of patients with chronic nonbacterial osteomyelitis
| Chief compliment | Sex | Age (years) | The time between first symptom and diagnosis(months) | Follow-up (months) | CRP (mg/dL) | ESR (mm/h) | SAA (μg/mL) | IgG (mg/dL) | BAP (μg/L) | TRAP5b (mU/dL) | Number of bones with high accumulation on FDG-PET | Bone lesions with high signal on T2-STIR MRI | BMD(g/cm2) | Z score | Treatment | Treatment response to first line therapy | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fever of unknown origin | F | 13 | 18 | 46 | 0.09 | 33 | 27 | 1722 | 37.4 | 338 | 8 | 33 | 0.921 | −0.8 | N + B | no response |
| 2 | Pain in the left hand | M | 15 | 3 | 44 | 0.01 | 5 | <5 | 1620 | 42.3 | 1870 | 8 | 24 | 0.726 | −3.7 | N | no response |
| 3 | Pain in the right foot | M | 12 | 12 | 45 | 0.49 | 35 | 56 | 1524 | 82.8 | 1170 | 1 | 29 | N/A | N/A | N | no response |
| 4 | Pain in both femurs | M | 12 | 4 | 56 | 2.56 | 59 | 143 | 1561 | 53.5 | 1050 | 8 | 8 | 0.582 | −2.1 | N + B | no response |
| 5 | Pain in both hands | F | 11 | 9 | 26 | 0.01 | 2 | <5 | 802 | 30.2 | 239 | 2 | 10 | 0.667 | −2.2 | N + B | clinical remission |
| 6 | Pain in the right foot | M | 12 | 5 | 48 | 0.01 | 1 | <5 | 1057 | 62.8 | 1620 | 3 | 3 | 0.742 | −1.5 | N + B | clinical remission |
| 7 | Fever of unknown origin | F | 15 | 3 | 52 | 0.4 | 18 | 26 | 1361 | 8.1 | 270 | 11 | 27 | 0.999 | −0.3 | N + B | partial response |
| 8 | Pain in both knees | F | 5 | 2 | 33 | 0.02 | 7 | <5 | 993 | 65.5 | 914 | 4 | 8 | N/A | N/A | N + B | clinical remission |
| 9 | Fever of unknown origin and pain in the left knee | M | 10 | 24 | 22 | 0.54 | 77 | 58 | 1561 | 49.49 | 2150 | 2 | 2 | 0.601 | −1.4 | N | partial response |
| 10 | Pain in both feet and knees | M | 13 | 13 | 31 | 0.04 | 5 | <5 | 1255 | 116.4 | 2430 | 4 | 4 | 0.688 | −2.1 | N + B | partial response |
| 11 | Pain in both feet | F | 10 | 11 | 31 | 0.01 | 4 | <5 | 1255 | 62.2 | 843 | 4 | 4 | 0.593 | −2.8 | N + B | clinical remission |
| 12 | Pain in both feet | M | 12 | 4 | 32 | 0.19 | 16 | 14 | 1150 | 94.2 | 1500 | 5 | 2 | 0.505 | −2.9 | N + B | partial response |
| 13 | Pain in the right foot | M | 8 | 5 | 29 | 0.01 | 2 | 6 | 1293 | 64.1 | 717 | 1 | 3 | 0.554 | −1.9 | N + B | partial response |
| 14 | Pain in both feet and knees | M | 10 | 3 | 22 | 3.49 | 51 | 50 | 879 | 72 | 1320 | 6 | 8 | 0.513 | −2.6 | N + B | partial response |
| Mean | Girls: 5 Boys: 9 | 11.3 | 8.3 | 37 | 0.6 | 23 | 48 | 1288 | 60 | 1174 | 4.8 | 11.8 | 0.7 | −2.0 | NSAIDs alone: 3 NSAIDs + Bisphosphonate: 11 | Clinical remission: 4 Partial response: 6 No response: 4 |
Abbreviations: F female, M male, CRP C-reactive protein, ESR erythrocyte sedimentation rate, SAA serum amyloid A, IgG immunoglobulin G, BAP bone alkaline phosphatase, TRAP5b tartrate-resistant acid phosphatase serum band 5bm, BMD bone mineral density, NNSAIDs, B Bisphosphonate