Table 2.

Details of the computerized cognitive training intervention for the studies included

Reference	Training program/ task Cognitive Domain Trained	Description of Training	Training Frequency Training Duration	Total hours of training Supervised/ Home-based	Control Group
Suo et al. [19] 2016	COGPACK Multidomain: memory, attention, response speed, executive functions, language	COGPACK: Exercises focused on memory, attention, response speed, executive functions, and language	26 weeks 52 sessions 90 min/session	78 Supervised	Active: watched videos on computer, followed by questions
Rosen et al. [18] 2011	Posit Science Multidomain: processing speed, accuracy in auditory processing	Auditory verbal repetition paradigm: 7 exercises aimed at improving processing speed and accuracy in auditory processing	5 weeks 24 sessions 100 min/session	36 Home	Active: 3 different computer-based activities (listening to audiobooks, reading online news, playing visuospatial computer game)
Lampit et al. [16] 2015	COGPACK Multidomain: memory, attention, response speed, executive functions, language	Exercises focused on memory, attention, response speed, executive functions, and language	12 weeks 3×/week 60 min/session	36 Supervised	Active: viewed 7 National Geographic videos per session on a computer with multiple choice questions
Belleville et al. [21] 2014	Customized program Executive Function: Attention	Alphanumeric equation task: judge accuracy of visually presented letter and number equations. Visual detection task: detect the red rectangles (press a button) in a series of white and red rectangles Groups: 1. Single repeated: Complete both tasks individually (focused attention) 2. Divided fixed: Complete 2 tasks simultaneously with divided attention (50%) 3. Divided variable: Complete two tasks simultaneously with different attention allocation levels (80%, 50%, 20%)	2 weeks 3×/week 1 h/session	6 Supervised	No Control
Lin et al. [17] 2014	RehaCom Executive Function and memory	Computer-assisted exercise focused on memory and executive function	10 weeks 6×/week 60 min/session	60 Supervised	Passive
Strenziok et al. [24] 2014	Multidomain: Brain Fitness (BF): auditory perception; Space Fortress (SF): visuomotor and working memory Rise of Nation (RoN): attention, motor processing, working memory, reasoning, visuospatial short-term memory, task-switching	1. Brain Fitness (BF): Adaptive auditory perception computer game 2. Space Fortress (SF): Complex skill acquisition computer game 3. Rise of Nations (RoN): Off-the shelf real-time strategy computer game	6 weeks 36 sessions 60 min/session	36 Supervised + Home (50–50%)	No Control
Lövden et al. [23] 2010	Customized program Multidomain: working memory, episodic memory, perceptual speed	Working Memory (3-Back, Memory updating, Alpha span) Episodic memory (Object-position memory, Number-noun pairs, Word lists) Perceptual speed (Choice reaction tasks, Comparison Tasks)	>4 months Average of 100 ± 3.7 sessions 60 min/session	Average of 100 Supervised	Passive: Pre-post MRI only
Antonenko et al. [20] 2016	Object-location Learning Paradigm Memory	Object-location Learning Paradigm: Learn the correct spatial locations of buildings on a street map. Five blocks of 120 stimulus-location pairing with a response interval of 3 s. Each block was followed by a cued recall and a recognition task	3 consecutive days 5 learning blocks/day	Unknown Unspecified	No Control
Heinzel et al. [22] 2014	n -Back training Executive Function: Working Memory	Adaptive n-back training, 3 runs (12 blocks/run) each session. Difficulty level increased according to individual performance (higher working memory load, shortened interstimulus interval (ISI). ISI ranged from 1500 to 500 ms in steps of 500 ms.	4 weeks 3×/week 45 min/session	9 Supervised	No control