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. 2017 Jul 11;8:23. doi: 10.1186/s13293-017-0144-8

Table 5.

Summary of articles describing sex differences in miscellaneous stress tests

Author (year) Sample size Age Study protocol Sampling points Sampling medium Results
0–1 year old Davis (1995) 36 30.99 ± 8.09 h Neonatal Behavior Assessment Scale 5×, 1 before, 4 after test Saliva Higher reactivity in boys
Eiden (2015) 217 9 months Laboratory Temperament Assessment Battery 4×, 1 before, 3 after test Saliva Cortisol increase in boys, not in girls
Grunau (2010) 32 4.2 ± 1.0 months Cortisol response after vaccination 3×, 1 before, 2 after Saliva No sex differences; pubertal status not assessed
1–7 years old De Weerth (2013) 42 68.0 ± 4.3 months CREST paradigm 6× (2 before, 4 after) Saliva No sex differences; pubertal status not assessed
Gunnar (2010) 151 3.81 ± 0.23 years Daycare attendance 2×/day on 2 days Saliva No sex differences; pubertal status not assessed
Hatzinger (2007) 102 4.91 ± 0.44 years MSSB 5× (2 before, 3 after) Saliva Higher reactivity in girls
Kryski (2013) 409 40.72 ± 3.51 months Matching task 6× (1 before, 5 after) Saliva No sex differences; pubertal status not assessed
Mills (2008) 214 4.14 ± 0.24 years Easy and difficult matching tasks 6×, 1 before, 5 after Saliva Further decreases in boys after initial decrease for both sexes
Plusquellec (2011) 376 18.85 ± 0.74 months Two unfamiliar situations (clown and robot) 2×, 1 before, 1 after Saliva No sex differences; pubertal status not assessed
Spinrad (2009) 84 54.07 ± 0.97 months Preschool Laboratory Assessment Battery 3×, 1 before, 2 after Saliva No sex differences; pubertal status not assessed
Yong Ping (2014) 94 29.9 ± 1.1 months Maternal separation 4× (2 before, 2 after) Saliva No sex differences; pubertal status not assessed
≥7 years old Psychological stress Daughters (2013) 132 16.1 ± 1.0 years Behavioral Indicator of Resiliency to Distress 4×, 1 before, 3 after Saliva Boys: higher baseline, greater peak. No sex differences in AUCg
Hackman (2012) 180 12–14 years Parent–adolescent conflict discussion 3× (2 before, 1 after) Saliva No sex differences; pubertal status not assessed
Minkley (2012) 93 17.86 ± 0.096 years Examination challenge (reproduction of knowledge or transfer and problem-solving) 2×, 1 before, 1 after Saliva Not statistically significant, but higher increases in boys. More in reproduction of knowledge group, but also greater in transfer and problem-solving group
Zijlmans (2013) 52 12.5 ± 1.21 years Social Evaluative Stress Test 7×, 1 before, 6 after Saliva Higher reactivity in boys
Physical stress Allen (2009) 235 12.7 ± 2.9 years Laboratory Pain Tasks Saliva: 3×, 1 before, 2 after Saliva/blood No sex differences; pubertal status not associated with reactivity
Blood: 2× (after)
Chiodo (2011) 16 Boys: 14 ± 0 years; girls: 13 ± 1 years Taekwondo competition 5× (2 before, 3 after) Saliva Lower overall values in girls, but higher peak.
Covelli (2012) 106 15.3 ± 1.1 years Cold water hand immersion 2×, 1 before, 1 after Saliva No sex differences; pubertal status not assessed
Frias (2000) 48 13–17 years Acute alcohol intoxication 1× (after); controls as reference Blood More pronounced increase in girls
Gecgelen (2012) 40 10.9–14.7 years Rapid maxillary expansion 13×, 1 before, 3 after, and 9 during a period of treatment Saliva No sex differences; pubertal status not assessed
Khilnani (1993) 98 2–20 years Elective surgery 2×, 1 before, 1 after Blood No sex differences; pubertal status not assessed
Kuhlman (2015) 121 12.8 ± 2.3 years Socially evaluated cold pressor test 7× (2 before, 5 after) Saliva No sex differences; pubertal status not assessed
Lopez-Duran (2015) 115 12.79 ± 2.26 years Socially evaluated cold pressor test 8× (2 before, 6 after) Saliva No sex differences; pubertal status not assessed
Stupnicki (1995) 29 Boys: 17.3 ± 0.8; girls: 16.4 ± 0.6 years Exercise 2×, 1 before, 1 after Blood Boys decrease in cortisol; girls increase in cortisol after exercise
Yfanti (2014) 97 89.73 ± 15 months Dental treatment 5×, 1 before, 4 after Saliva No sex differences; pubertal status not assessed