Table 2.
Respiratory functions on days 4 and 10 post-infection
| Rrs cmH2O.s/mL | Crs mL/cmH2O | Rn cmH2O.s/mL | G cmH2O/mL | H cmH2O/mL | FEV 0.05 mL | ||
|---|---|---|---|---|---|---|---|
| Day 4 | DMSO (n = 3) | 0.61 ± 0.10 | 0.05 ± 0.0 | 0.27 ± 0.07 | 3.9 ± 0.5 | 19.4 ± 1.4 | 0.87 ± 0.18 |
| Sirolimus (n = 4) | 0.66 ± 0.17 | 0.04 ± 0.0 | 0.28 ± 0.17 | 4.6 ± 1.1 | 25.0 ± 3.2 | 0.79 ± 0.08 | |
| IAV (n = 7) | 1.44 ± 0.99 * | 0.03 ± 0.01* | 0.40 ± 0.24 | 9.8 ± 6.1* | 36.5 ± 18.3* | 0.59 ± 0.41 | |
| Both (n = 4) | 0.83 ± 0.13 | 0.04 ± 0.0 | 0.28 ± 0.05 | 5.7 ± 1.2 | 22.7 ± 2.4 | 0.48 ± 0.39 | |
| Day 10 | DMSO (n = 5) | 0.56 ± 0.05 | 0.04 ± 0.00 | 0.22 ± 0.04 | 4.2 ± 0.4 | 20.7 ± 1.6 | 0.84 ± 0.24 |
| Sirolimus (n = 5) | 0.57 ± 0.06 | 0.04 ± 0.01 | 0.18 ± 0.05 | 4.7 ± 0.6 | 22.4 ± 5.2 | 0.95 ± 0.11 | |
| IAV (n = 5) | 0.96 ± 0.42* | 0.03 ± 0.01 | 0.35 ± 0.28 | 6.3 ± 1.5* | 30.7 ± 8.3 | 0.53 ± 0.48 | |
| Both (n = 4) | 1.0 ± 0.62 | 0.03 ± 0.01 | 0.25 ± 0.02 | 8.8 ± 6.3 | 45.0 ± 34.1 | 0.47 ± 0.53 | |
Rrs, thoracic resistance; Crs, thoracic compliance; Rn, large airway resistance; G, lung tissue damping (resistance); H, lung tissue elastance (stiffness); FEV 0.05, forced expiratory volume at 50 ms
Values are mean ± SD
*designates p < 0.05 compared with DMSO