Table 3.

Characteristics associated with progression from multiple autoantibody status to type 1 diabetes (n=121)

Variable	Acceleration factor estimate (95% CI)	p value
HLA-DR3/4 (yes vs no)	0.50 (0.32, 0.80)	0.004
Age at seroconversion (years)	1.17 (1.07, 1.28)	<0.001
Hispanic/AA vs NHW	1.67 (0.74, 3.78)	0.22
GP vs FDR	0.99 (0.61, 1.61)	0.97
Sex (female vs male)	0.94 (0.60, 1.46)	0.77

Accelerated failure time model analysis for time from multiple autoantibody status to progression to diabetes

Acceleration factor >1 indicates slowing of progression. Acceleration factor <1 indicates increased rate of progression

AA, African-American; FDR, participant with first-degree relative; GP, general population participant; NHW, non-Hispanic white