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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Chem Rev. 2015 Mar 19;115(9):3518–3563. doi: 10.1021/cr500638n

Figure 13.

Figure 13

Physiological micro-molar concentrations of albumin inhibit fibre formation. (a) Kinetics of Aβ fibre formation in the presence of: no albumin (red); 1 μM (dark green); 3 μM (green); 5 μM (light blue); and 10 μM (dark blue) of albumin. (b) Competitive effects of albumin on total Aβ fibrils generated with a strong direct correlation between fraction of fibres generated and the calculated fraction of Aβ free to form fibres (not bound to increasing concentrations of albumin), based upon a Kd of 5 mM. Adapted from Stanyon et al.(352).