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AR-inhibition regulates cell viability of Thp1 cells via Nrf2 activation. The control-siRNA and Nrf2-siRNA-transfected Thp1 cells were treated with HG ± fidarestat for 48 h, and the cell viability was determined by MTT assay. Data represent in mean ± SD (n = 6). ∗p < 0.01 versus control; #p < 0.01 versus HG; NS = nonsignificant versus HG-treated cells. The inset shows Western blots for Nrf2 in control and siRNA-transfected cells. GAPDH = loading control.
