Table 3.
Results of simple and multiple Cox regression models for overall survival. Hazard ratios (HR) with 95% confidence intervals (CI) and p values (p) and proportions of explained variation (PEV). Full model PEV = 21.8%.
| Variables | Simple HR (95%, CI) |
p value | PEV | Multiple HR (95%, CI) |
p value | PEV |
|---|---|---|---|---|---|---|
| Alb < 35 | 1.01 (0.61–1.68) | 0.97 | 0.0 | 0.92 (0.54–1.58) | 0.763 | 0.0 |
| CRP > 1 | 1.63 (1.12–2.38) | 0.011 | 1.6 | 1.47 (0.97–2.24) | 0.070 | 0.3 |
| N1∗ | 3.42 (2.01–5.82) | <0.001 | 12.4 | 1.93 (0.98–3.77) | 0.007 | 3.1 |
| N2∗∗ | 3.13 (2.21–4.43) | <0.001 | 12.4 | 2.37 (1.50–3.74) | <0.001 | 3.1 |
| Nres∗∗∗ | 0.90 (0.77–1.05) | 0.18 | 0.3 | 0.70 (0.59–0.83) | <0.001 | 3.2 |
| nEAC∗∗∗∗ | 1.85 (1.21–2.84) | 0.005 | 4.2 | 1.03 (0.62–1.72) | 0.903 | 1.2 |
| nESCC∗∗∗∗ | 0.82 (0.78–1.42) | 0.482 | 4.2 | 0.85 (0.47–1.53) | 0.589 | 1.2 |
| One-stage surgery | 0.56 (0.33–0.94) | 0.027 | 1.5 | 0.80 (0.46–1.41) | 0.447 | 0.1 |
| UICC | <0.001 | 13.5 | 0.013 | 3.0 | ||
| I versus 0 | 0.59 (0.26–1.30) | 0.186 | 0.77 (0.33–1.82) | 0.555 | ||
| II versus 0 | 2.03 (1.00–4.13) | 0.052 | 1.94 (0.89–4.21) | 0.093 | ||
| III + IV versus 0 | 2.90 (1.45–5.84) | 0.003 | 2.58 (1.08–6.14) | 0.033 |
∗Effect of at least one pos. LK has time-dependent effect (p = 0.001 in simple model, p = 0.002 in multiple model). HR and 95% CI given are evaluated at 48 months; p value given refers to whole (time-dependent) effect, including neoadjuvant-treated and untreated cases. ∗∗N1 and N2 together also in “simple” model, including neoadjuvant-treated and untreated cases. ∗∗∗HR for log2-transformed variables quantify the effect of a doubling of the respective variable. ∗∗∗∗Neoadjuvant therapy and tumor biology (EAC and ESCC) exhibit a significant interaction (p = 0.021) in the model containing only these two variables but not in the multivariable model (p = 0.604). Thus, the neoadjuvant therapy effect is given separately for nEAC and nESCC.