Table 4.
Multiple Cox regression models for overall survival for various proposed ways to account for CRP and albumin effect. Results for multiple Cox regression model refer to adjustment for the variables reported in Table 3. Hazard ratios (HR) with 95% confidence intervals (CI) and p values (p) and proportions of explained variation (PEV). Full model PEV = 21.8%.
| Variables | Multiple HR (95%, CI) |
p value | PEV |
|---|---|---|---|
| Alb < 35 | 0.92 (0.54–1.58) | 0.763 | 0.0 |
| CRP > 1 | 1.47 (0.97–2.24) | 0.070 | 0.3 |
| GPS | 0.287 | 0.3 | |
| 1 versus 0 | 1.37 (0.93–2.04) | 0.116 | |
| 2 versus 0 | 1.17 (0.52–2.60) | 0.708 | |
| mGPS | 0.159 | 0.3 | |
| 1 versus 0 | 1.55 (0.99–2.43) | 0.056 | |
| 2 versus 0 | 1.17 (0.53–2.60) | 0.705 | |
| log(CRP/Alb)∗ | 1.02 (0.95–1.09) | 0.684 | 0.0 |
| CRP/Alb > 0.95 | 0.89 (0.44–1.84) | 0.759 | 0.0 |
∗HR for log2-transformed variables quantify the effect of a doubling of the respective variable.