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EBV-infected cells elicit reactive oxygen species- (ROS-) induced DNA damage via activation of NADH oxidase (NOX) family NADPH oxidase. This leads to persistent infection and inflammation via activation of inflammasome IFI16 and ASC that trigger posttranscriptional modifications of viral and host genes that are critical for promoting B-cell immortalisation, malignant transformation, and subsequently EBV-related tumorigenesis.
