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. 2017 Jun 26;40(2):465–473. doi: 10.3892/ijmm.2017.3040

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Copyright: © Song et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of Periplaneta americana extract (PAE) on Janus-activated kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling and Smad3 activities in burn wound specimens in vivo. (A) Immunohistochemical (IHC) analysis of JAK/STAT3 signaling cascade, Smad3 and its phos-phorylation in PAE-treated or control tissues. Representative images are shown (magnification, ×400). (B) Western blotting of JAK/STAT3 signaling proteins, Smad3 and its phosphorylation using β-actin as a loading control. Data are expressed as mean ± SD. The arrows in (A) indicate p-JAK1/JAK1, p-JAK2/JAK2, p-STAT3/STAT3, p-Smad3/Smad3 expression in the nucleus and cytoplasm, respectively.