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. 2017 Jun 19;6(1):1333883. doi: 10.1080/20013078.2017.1333883

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© 2017 Intravacc, part of the Ministry of Health Welfare and Sports

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Growth of Neisseria meningitidis in benchtop batch cultivation. Upper panel shows the growth pattern of the bacteria (black squares) and shows that OMVs (green diamonds) are increasingly produced after the exponential growth phase. The lower panel shows the size of OMVs. The size of OMVs released in the exponential growth phase is similar to the size of OMVs produced in the stationary phase. The increased size of OMVs in the first 6 h of the cultivations deviates, possibly caused by the increased measurement error due to concentrations in the range of the lower limit of detection.