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. 2017 Jun 9;40(2):337–346. doi: 10.3892/ijmm.2017.3016

Figure 8.

Figure 8

miR-16-1/HSP70 pathway is involved in anastomotic fibrosis in IL-10−/− mice undergoing ICR and can be regulated by TPL. (A) Relative expression of miR-16-1 at the anastomosis site in each group; (B) results of western blot analysis for HSP70 in each group. The relative expression of HSP70 was statistically calculated compared to the β-actin level; (C) the ratios of the mean density of HSP70 at the anastomosis site in each group. (D) Relative expression of HSP70 at the anastomosis site in each group; the data are presented as the average ± SD of 6 independent experiments. *P<0.05, significantly different from the WT group; #P<0.05, significantly different from the control group; +P<0.05, significantly different from the ST-ICR group. HSP70, heat shock protein 70; ICR, ileocecal resection; TPL, triptolide; WT, wild-type; ST-ICR, saline-treated-ICR group; TT-ICR, triptolide-treated ICR group.