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. 2017 Jun 1;7(8):2250–2260. doi: 10.7150/thno.18816

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Triptolide Inhibits the Production of Cytokines and Chemokines by Suppressing the NFκB Pathway of the Tumour-related Inflammatory Cells. A-E) The Bio-plex Multiplex Suspension Array of cytokines in tumours, Mean ± S.D., n=3, * below detection limits. F) Immunoblotting assays showed that triptolide inhibited the NFκBp65 phosphorylation induced by VNP infection in Jurkat cells. G) NFκBp65 luciferase reporter assays showed that triptolide inhibited the transcriptional activity of NFκBp65 which was activated by VNP infection in Jurkat cells. The mean value of the control group was defined as 1.0. Mean ± S.D., n=3. H) The EMSA assay showed that triptolide exhibited a dose-dependent inhibition on the TNF-α-induced DNA binding activity of NFκBp65 in Jurkat cells. I) The EMSA assay showed that triptolide exhibited a dose-dependent inhibition on the VNP-induced DNA binding activity of NFκBp65 in Jurkat cells.