Table S3.
IAV and SP coinfection-associated inflammatory effect (fold) varied with cytokines, day of introducing SP post-IAV infection, and exceedance risks at 0.8, 0.5, and 0.2
| Cytokine | Exceedance risk
|
||
|---|---|---|---|
| 0.8 (more likely) | 0.5 (likely) | 0.2 (less likely) | |
| Day 1 | |||
| IL6 | 0 (0–127)a | 0 (0–147) | 165 (101–230) |
| TNFα | 48 (0–790) | 760 (286–1,233) | 1,895 (1,601–2,189) |
| IFNγ | 27 (0–575) | 99 (0–494) | 214 (0–526) |
| Day 7 | |||
| IL6 | 0 (0–151) | 166 (101–231) | 408 (177–639) |
| TNFα | 907 (483–1,331) | 1,899 (1,604–2,194) | 3,339 (2,568–4,109) |
| IFNγ | 114 (0–483) | 215 (0–527) | 360 (0–933) |
| Day 9 | |||
| IL6 | 0 (0–133) | 16 (0–155) | 213 (131–294) |
| TNFα | 261 (0–920) | 1,006 (613–1,399) | 2,176 (1,822–2,531) |
| IFNγ | 49 (0–547) | 124 (0–478) | 243 (0–583) |
Note:
a
Median (95% CI).
Abbreviations: IAV, influenza A virus; SP, Streptococcus pneumoniae.