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. Author manuscript; available in PMC: 2017 Jul 11.
Published in final edited form as: Virology. 2017 Mar 21;506:34–44. doi: 10.1016/j.virol.2017.03.002

Fig. 8.

Fig. 8

The HIV-1 ASP RNA promotes HIV-1 latency by recruiting PRC2 to the 5′LTR leading to suppressive epigenetic marks at Nuc-1. ChIP assays assessing the presence of the histone lysine methyltransferase EZH2 (Panel A) and histone H3 with trimethylated lysine 27 (H3K27me3; Panel B) at Nuc-1 in Jurkat E4, JE4-LVX, and JE4-ASTmut before and after treatment with the EZH2 specific inhibitor, EPZ-6438. Graphs report average and standard deviation calculated from three replicate samples.