. Author manuscript; available in PMC: 2018 Jul 1.

Published in final edited form as: J Mol Endocrinol. 2017 Apr 18;59(1):R33–R46. doi: 10.1530/JME-17-0042

Table 2.

Islet Chemokines in Polygenic Rodent Models of Obesity and Diabetes.

Animal Model (species)	Relevant Human Condition	Islet Chemokine Production	References
BB (rat)	Autoimmunity/T1D	Yes	(Kuttler, et al. 2007)
GK (rat)	Insulin Resistance/T2D	Yes	(Ehses et al. 2009)
MLDS (mouse/rat)^*	Insulin insufficiency/T1D	Yes	(Burke et al. 2016; Martin et al. 2007; Martin et al. 2008a)
NOD (mouse)	Autoimmunity/T1D	Yes	(Burke et al. 2016; Martin et al. 2008a; Welzen-Coppens et al. 2013)

, MLDS, multiple low doses of streptozotocin (STZ). STZ impacts multiple mouse and rat strains; thus, we have included it under the polygenic models.